KEGG analysis (Figure 1E) revealed that these TRGs were significantly enriched in some classical tumor-related pathways (Transcriptional misregulation in cancer, IL-17 signaling pathway, Arachidonic acid metabolism, Influenza A, C-type lectin receptor signaling pathway, Bladder cancer, Serotonergic synapse, Malaria, Shigellosis, and Melanoma). The gene discussed is CLEC4D; the disease is shigellosis.