MUC16, IDH2, KIT, TTN, DNMT3A, PRUNE2, UBR4, WT1, AHNAK, AHNAK2, CC2D2A, MACF1, NF1, PCLO, and VPS13D were the top 15 genes with the highest mutation rate in AML patients with low TRP scores (Figure 4C). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.