MUC16, IDH2, KIT, TTN, DNMT3A, PRUNE2, UBR4, WT1, AHNAK, AHNAK2, CC2D2A, MACF1, NF1, PCLO, and VPS13D were the top 15 genes with the highest mutation rate in AML patients with low TRP scores (Figure 4C). This evidence concerns the gene PRUNE2 and acute myeloid leukemia.