Based on GSEA, six cancer-related pathways (MAPK signaling pathway, TOR signaling pathway, Apoptosis, Wnt signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway) were identified, which may be positively regulated by this signature, which provided insights for exploring the mechanism of AML (Figure 3F). Here, TNF is linked to acute myeloid leukemia.