DNMT3A, FLT3, RUNX1, NPM1, TP53, NRAS, CACNA1B, IDH2, MUC16, TTN, ALOX12B, ASXL1, ATP10B, BBS12, and BRINP3 were the top 15 genes with the highest mutation rate in AML patients with high TRP scores (Figure 4C). The gene discussed is CACNA1B; the disease is acute myeloid leukemia.