BACE1 and Cognitive impairment: Other than cognitive impairment, phenotypic alterationswere also reported due to mutated mice.54 A transgenic mouse with mutations at APP and presenilin 2 on chromosome1 or only at APP can also be created with closely related featuresto FAD.55 Even though the mouse modelsof APPG-F for BACE1 inhibitors (BACE1 is beta-siteAPP-cleaving enzyme 1 responsible for breaking down APP) and APPP11JL for immunotherapies have been discovered, these are notsuitable for the more prevalent sporadic AD.56