In addition to the peripheral distortion of insulin sensitivity,providing fat-loaded diets for almost 10–14 weeks to the ratsor mice instead of a regular diet also potentially induces centralinsulin resistance up to some extent.63,64 The fattydiet comprises 25% fat, 20% protein, and 50% carbohydrate.64 Dementia and AD have long been characterizedto possess distorted brain insulin signaling. Here, INS is linked to Alzheimer disease.