Moreover, this model also represents gliosis, synaptic disruption,and neuronal death.58 The model depictsthe features of AD earlier than in other transgenic models; however,phosphorylated tau pathology is less prevalent than amyloid plaquesin this model.52 Further, proinflammatorycytokines and immune markers through microglial and caspase-3 activationin the brain regions of the cortex and hippocampus have been reported,indicating neuroinflammation and subsequent apoptosis-generated59 neurodegeneration.60 This evidence concerns the gene MAPT and Alzheimer disease.