In a recent investigation of 17 tissue markers (AR, CD20, CD4, CD8, CD163, EPRS, ER, FASN, H3K27, IGF1R, IR, Ki67, phospho-mTOR, PR, PTEN, RXR, and VDR) in breast tumor tissue from 5,914 participants in NHS and NHSII, the correlations between pathologist and Definiens assessments ranged from weak to strong and were ≥0.55 for 10 of the 17 markers analyzed (44). The gene discussed is CD4; the disease is breast neoplasm.