In turn, sex, allergic diseases, hypertension, tumors, gastrointestinal and osteoarticular diseases, P-LCR, platelet count, eosinophil count, MPV, eosinophil ratio, basophilic granulocytes, lymphocyte count, lymphocyte ratio, basophil ratio, LDL/HDL ratio, globulin, magnesium, ESR, PT activity, cystatin C, and the percentage of granulocytes were associated with a reduced risk of very severe COPD. This evidence concerns the gene CST3 and chronic obstructive pulmonary disease.