As an important transmitter of extracellular information from the cell surface to the intracellular space, MAPK signaling has been implicated in AD with various mechanisms, including amyloid beta (Aβ) toxicity, increasing RAGE expression, tau hyperphosphorylation, induction of apoptosis, and deregulated autophagy (Kheiri et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.