The analysis of single-gene contributions to DS has revealed the Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (DYRK1A), a DS candidate gene located in the 21q22.2 human chromosome region (Duchon and Herault, 2016), as a good candidate to contribute to cerebellar DS phenotypes. This evidence concerns the gene DYRK1A and Dravet syndrome.