PPARG and myeloid sarcoma: For instance, PPARγ expression in CNS myeloid cells was shown to control inflammatory activation in experimental autoimmune encephalomyelitis (EAE) (Hucke et al., 2012) and its agonist pioglitazone decreases systemic inflammatory activity and the development of new brain lesions in MS obese patients (Negrotto et al., 2016).