When comparing COVID-19 to TB patients, the calculation of a NUM score based on seven biomarkers (ApoA1, CRP, ferritin, IL-6, IP-10, SAA1/A2, and S100A12), resulted in a sensitivity of 91% (CI: 84 · 1 to 95 · 3) with specificity of 87% (CI: 74 · 3 to 93 · 9) applying a cut-off of at least four positive markers (AUC: 0 · 95; Figure S6). Here, S100A12 is linked to COVID-19.