Furthermore, it can promote the replication of a wide range of clinically important viruses including hepatitis B and C, Parainfluenza VirusType 3, Respiratory Syncytial and Influenza A viruses, as shown in transgenic mouse models including BMAL1 KO animals,6,27,32,33,34,35 emphasizing a central role of the circadian clock in regulating viral infection.36 The gene discussed is CLOCK; the disease is viral infectious disease.