We further analyzed the coexpression of genes in the TGFB pathway with immune-related genes and could find that genes within the TGFB pathway had a strong positive correlation with immune-related genes in Local-SCLC cohort (Supplementary Figure 3A, p < 0.05), while in the George-SCLC cohort, this strong positive correlation was mainly occurred in RHOA, TGFB1, and TGFBR2 (Supplementary Figure 3B, p < 0.05). This evidence concerns the gene RHOA and small cell lung carcinoma.