Among the central genes, S100A8/9, MMP9, SOCS3 and IL1R1 have been widely reported to be associated with the progression or tissue injuries in AP (Norman et al., 1996; Farkas et al., 2014; Shi et al., 2018; Qin et al., 2019). The gene discussed is SOCS3; the disease is alkaline phosphatase measurement.