Lactobacillus is implicated with beneficial effects in preventing and reducing inflammation-related diseases, such as inflammatory bowel disease (IBD) and non-alcoholic fatty acid liver diseases, accompanied by gastrointestinal barrier function enhancement and a decrease in pro-inflammatory cytokine levels (such as IL-6 and IL-1β) (Azad et al., 2018; Aghamohammad et al., 2022). The gene discussed is IL1B; the disease is inflammatory bowel disease.