H2S can attenuate nuclear factor erythroid 2-related factor 2/nuclear factor kappa B (Nrf2/NF-κB) signals, weaken oxidative stress, and inhibit mitochondrial ROS production to preserve mitochondrial function, decrease cardiac muscle infarct size, preserve cardio-contractile function, activate or rescue endothelial nitric oxide synthase (eNOS) functionality, and relieve heart failure (Testai et al., 2016; LaPenna et al., 2021; Ling et al., 2021). This evidence concerns the gene NOS3 and heart failure.