NPR3 and colitis: A recent study constructing activating mutant mice with the guanylate cyclase C (Gucy2c) gene found that mutant mice have increased intestinal cGMP, leading to loss of overall internal environmental homeostasis, fluid ion imbalance, dysregulation of the intestinal microbiota, and susceptibility to colitis, suggesting that gut-associated cGMP signaling pathway may mediate colitis and flora dysbiosis (Mishra et al., 2021).