Mechanistically, DNMT3A deficiency leads to hypomethylation, which impairs the function and regeneration of the intestinal epithelial barrier, making mice more susceptible to DSS-induced colitis, implying a role for impaired epithelial DNMT3A function in the etiology of IBD (Fazio et al., 2022). The gene discussed is DNMT3A; the disease is colitis.