To dissect whether and how MIR31 mediate or is mediated by the transducers in colitis, we further analyze the effect of MIR31-involved reactions on the proliferative epithelial cell number, including the inhibitions of MIR31 on Gp130, IL17RA, Axin1 and Lats1/2 (represented by parameters γGpMIR, γI17RMIR, γAxiMIR and γLatMIR, respectively), and the promotions of p-p65 and p-STAT3 on MIR31 (represented by kMIRp65 and kMIRpST, respectively) as shown in Figure 5A. The gene discussed is STAT3; the disease is colitis.