These receptors regulates glucose uptake by muscle tissues (e.g., H1) [54], glucose tolerance (e.g., α-1 adrenergic) [55], glucose-stimulated insulin secretion by pancreatic β-cells and tissue insulin resistance and diabetes (D2R and M3R) [56–60] which clearly reflected by low HOMA-B index in OLZ treated rats in the current study. Here, INS is linked to diabetes mellitus.