PARP-1 can also recruit protein MRE11, ATM (ataxiatel angiectasia mutated) to suppress the transcription factors E2F4 and P130 complexes and impact the expression of breast cancer susceptibility genes BRCA1 and RAD5 [25], which transiently protects the DNA gaps and inhibits recombinant. This evidence concerns the gene SHPRH and breast cancer.