Several genes have been discovered to be differentially methylated in AD brain autopsy samples using “Illumina Infinium Human Methylation450K arrays”, including those genes previously identified as carrying genetic variations for AD, such as BIN1 (amphiphysin II) or ANK1 (ankyrin-1) (Altuna et al., 2019b, Lunnon et al., 2014). This evidence concerns the gene ANK1 and Alzheimer disease.