Hypermethylation of BDNF, CRMP2, NR3C1, and SLC6A4 is associated with Depression and MDD (Xiang et al., 2021, Li et al., 2021, Borçoi et al., 2021, Li et al., 2019, Schiele et al., 2021, Sanwald et al., 2021, de Assis Pinheiro et al., 2021). The gene discussed is DPYSL2; the disease is major depressive disorder.