Cluster 7 had equivalent proportions of HD and control iAstros and had a relatively high expression of DNA repair and transcription-related genes, like FANCA and EZH2. Overall, control states were enriched for astrocyte functions involved in neural support and neuroinflammation, while HD states were enriched for adhesion, ECM, and immature markers. This evidence concerns the gene EZH2 and Huntington disease.