Glutamate receptor (z = −2.24, p < 0.001), endocannabinoid neuronal synapse (z = −2.71, p < 0.04), and neuropathic pain (z = −3, p < 0.05) signaling pathways were among the inhibited pathways in HD iAstros and contained genes encoding multiple glutamate receptors, GRIA1-2 and GRIN2A-B. The gene discussed is GRIA1; the disease is Huntington disease.