SLC1A2 and Huntington disease: ,16,18,19,56,57,58 The evidence of dysfunctional glutamate regulation in our adult-onset HD iAstro lines is consistent with prior studies demonstrating a similar phenotype in juvenile-onset HD iPSC-derived astrocytes,9 and with loss of GLT1 expression in mice with HTT-160Q selectively expressed only in astrocytes.56