NEAT1 and Huntington disease: While most of the transcriptional cell states we identified in both human and mouse data were represented in HD and control samples, with shifts in percent composition in each condition, the HD iAstro data revealed complete loss of a unique control cell state that showed high expression of NEAT1, a gene associated with the stability of nuclear paraspeckles and thought to function through interactions with RNA binding and other proteins and RNAs, thus affecting transcription.28