Interestingly, cardiac hypertrophy signaling was the most significantly inhibited pathway predicted in the 8-week striatal R6/2 astrocytes (z = −0.447, p < 0.008) due to expression of genes such as Camk2g, Chuk, and Fgf14, but was predicted to be activated in 12-week striatal R6/2 astrocytes (z = 0.302, p < 6e-4). The gene discussed is CHUK; the disease is cardiac hypertrophy.