RRBP1 and Huntington disease: HES1 overexpression was one of the most significantly enriched transcription factors in R6/2 12-week astrocytes along with the dysregulation of several HES genes in HD iAstros; this is consistent with epigenetic dysregulation of a HES family transcription factor (HES4) associated with striatal degeneration in HD postmortem cortex.66