Recently, it was reported that ELOF1 plays a crucialrole in recruitingUV Stimulated Scaffold Protein A (UVSSA) to lesion-stalled Pol II.UVSSA recruits the deubiquitylating enzyme USP7, protecting CSB (Cockaynesyndrome group B (CSB) protein) from proteasomal degradation mediatedby the ubiquitin-selective segregase VCP (p97) (Supporting Information Figure 1A).34 Taking the positive role of USP7 in Wnt−β-catenin signaling-mediatedgrowth of colorectal carcinoma cells into consideration, we hypothesizedthat this axis might play a role in ELOF1-mediated decrease in β-cateninnuclear accumulation. This evidence concerns the gene VCP and colorectal carcinoma.