Loss of CAB39expression led to marked inhibition of expression of the Wnt pathway-relatedgenes such as AXIN2, CCND1, CLDN1, CDH2, CTNNB1, MYC, LEF1, and MMP7,which is consistent with previous studies showing the associationof the inhibition of these genes with decreased tumor progressionand β-catenin nuclear retention.31−33 Furthermore, these resultssupport the critical role of nuclear β-catenin in Wnt−β-cateninsignaling in SW480 APC-mutant cells. The gene discussed is CTNNB1; the disease is neoplasm.