APC and colorectal cancer: Moreover,it has been shown that USP7 acts as a Wnt signaling inhibitorin APC-mutated colorectal cancers by restoring β-cateninubiquitination, inhibiting tumor growth as evident in xenograft modelsgrowth suppression.36,37 We postulated that the ELOF1-UVSSA-USP7axis is involved in the reduced β-catenin nuclear accumulationwith ELOF1 being a regulator of the process.