Lifestyle changes combined with diet and exercise resulted in improved menstrual patterns in 65% of overweight/obese women with polycystic ovary syndrome, and significantly higher IRS1 and GLUT1 mRNA levels were found in the endometrium of these women with improved menstrual function, suggesting that lifestyle interventions can improve insulin sensitivity in patients (113). This evidence concerns the gene IRS1 and polycystic ovary syndrome.