Although the SYT4 mRNA reduction is characteristic of undifferentiated, fetal beta cells, a fully, dedifferentiated state is unlikely, as it is not seen in adults (except in insulinomas), and since it is well known that fetal beta cells, exposed to glucose, as it takes place in pregnant T1D patients, develops into the adult phenotype. The gene discussed is SYT4; the disease is pancreatic insulinoma.