CYP17A1 and Hypertension: In p17OHD, P450c17, with some remaining function, maintains certain activity in estrogen synthesis that result in various degrees of female secondary sexual characteristics development and mild symptoms of mineralocorticoid hyperactivity [hypertension, 12.5% (1/8); hypokalemia, 37.5% (3/8)] due to the limited overproduction of DOC.