INS and type 2 diabetes mellitus: Furthermore, the direction of the indirect effects of three traits favored a potential mediating effect of T2DM on the causal association between traits and SBP (Supplementary Table 7, Figure 3), and the proportion of the medicating effect by T2DM for the traits “fasting insulin,” “aspartate aminotransferase,” and “standing height” was 33.6%, 10.2%, and 6.9%, respectively (Supplementary Table 7).