According to the IVW, MR–Egger and weighted median methods, genetically predicted RA was found to be positively associated with CRP risk (IVW method, OR, 1.02; [95% CI, 1.01-1.03], P<0.0001; MR-Egger method, OR, 1.04; [95% CI, 1.02-1.05], P<0.0001; weighted median method, OR, 1.03; [95% CI, 1.02-1.04], P<0.0001). Here, CRP is linked to rheumatoid arthritis.