reported for the first time the role of PI3K/AKT/mTOR in the pancreas of patients with PCOS: low expression of the PI3K/AKT/mTOR pathway in the pancreas leads to impaired insulin sensitivity, decreased β-cell function and quality, and thus IR, and also demonstrated for the first time that nanocurcumin restores insulin sensitivity in patients with PCOS effective effect. Here, MTOR is linked to polycystic ovary syndrome.