In model rats treated with Bu-shen-zhu-yun decoction (a traditional Chinese herbal remedy for infertility), protein expression in the PI3K/AKT/mTOR pathway was significantly upregulated, while apoptosis-related proteins were significantly downregulated in PCOS rats, suggesting that apoptosis can be improved by enhancing PI3K/AKT/mTOR protein expression (72). This evidence concerns the gene AKT1 and Infertility.