INS and polycystic ovary syndrome: reported for the first time the role of PI3K/AKT/mTOR in the pancreas of patients with PCOS: low expression of the PI3K/AKT/mTOR pathway in the pancreas leads to impaired insulin sensitivity, decreased β-cell function and quality, and thus IR, and also demonstrated for the first time that nanocurcumin restores insulin sensitivity in patients with PCOS effective effect.