The results showed that age (OR=1.03, 95%CI 1.011-1.055, P=0.003), TyG index (OR=1.53, 95%CI 1.008-2.319, P=0.046), HS-CRP (OR=1.81, 95%CI 1.349-2.415, P<0.001), SUA (OR=1.01, 95%CI 1.002-1.006, P=0.001), HDL-C (OR=0.29, 95%CI 1.349-2.415, P=0.014), eGFR (OR=0.95, 95%CI 0.932-0.964, P<0.001) and Male (OR=0.62, 95%CI 0.385-0.989, P=0.045), these were the risk factors for early renal impairment in patients with hypertension (P<0.05, see Table 5). The gene discussed is CRP; the disease is Hypertension.