PPARA and liver dysplastic nodule: In addition, Annexin A1 in diabetic mice regulates the AMPK-PPARα-CPT1 pathway to attenuate inflammation in the pathogenesis of DN (87), whereas fenofibrate could also attenuate renal fibrosis through blocking the canonic Wnt signaling and activating the antioxidant effects (88), together indicating the important role of PPARα in DN.