FGF21 and obesity due to melanocortin 4 receptor deficiency: (174) revealed a positive impact of adipose-PGC1-α on distal organ systems, with beneficial effects on HO-1 levels, reversing obesity-linked cardiometabolic disturbances by uncoupling protein 1 (UCP1), fibroblast growth factor 21 (FGF21), and pAMPK signaling, with a reduction in inflammatory adipokines.