It was also suggested that the degree of obesity might be associated with the risk of developing islet autoantibodies in adults with T2D - among 204 patients with T2D and excess body weight, the presence of at least one of the three antibodies (GADA, IA2, and ZnT8A) was found in 6.4% of all subjects and in as many as 12.8% when considering those with severe obesity (BMI > = 40 kg/m2) (29). This evidence concerns the gene PTPRN and obesity due to melanocortin 4 receptor deficiency.