Among the top decreased proteins in infertile IOF, the expression of Small RNA binding exonuclease protection factor la (SSB), Myosin heavy chain 10 (MYH10), Heat shock protein family A (Hsp70) member (HSPA)9 and WD repeat domain 61 (WDR61) was significantly decreased in infertile organoid cells compared to fertile organoid cells respectively (Figure 6B). The gene discussed is SKIC8; the disease is Infertility.