For instance, ovarian cancer (Pten/Apc knockout model: SCC = 0.107, p-value = 9.35e-41; Arid1a/Pten knockout model: SCC = 0.101, p-value = 2.71e-24) and endometrial cancer (Trp53/Cdh1 knockout model: SCC = 0.256, p-value = 1.03e-191; Pten ± model: SCC = 0.120, p-value = 2.92e-39) were found to be positively associated with estrus. This evidence concerns the gene PTEN and ovarian cancer.