ROS1 and brain glioblastoma: It has been reported that 26 genes fuse with ROS1. With the advances in sequencing technology, many new genes have been reported to fuse with ROS1. Natural ROS1 rearrangement was first found in the human brain glioblastoma cell line U118MG (Birchmeier et al., 1987; Charest et al., 2003).