P2RX7 and neoplasm: Thus, while overstimulation of the receptor activates a large pore in the membrane that induces tumor cell death and inhibits tumor growth (Di Virgilio et al., 2018), tonic activation of P2RX7 supports the growth, migration, and invasiveness of tumors in vivo in several types of cancer (Adinolfi et al., 2012; Qiu et al., 2014; Amoroso et al., 2015; Amoroso et al., 2016).