P2RX7 and cancer: Moreover, P2RX7 activation also promotes cytokine release, angiogenesis, and adaptation to serum deprivation (Adinolfi et al., 2005; Ferrari et al., 2006; Jelassi et al., 2011; Amoroso et al., 2012; Gomez-Villafuertes et al., 2015), thereby favoring cancer cell survival (Gilbert et al., 2019).