SERPINF1 and colon carcinoma: Previous studies demonstrated that surface-modified PLGA-NPs were used for topical ocular drug delivery to treat the acquired retinal vasculopathies (Dandamudi et al., 2021); PEDF gene loaded in PLGA–NP significantly inhibited in vitro CT26s (colon carcinoma cell line) proliferation and the growth of colon carcinoma in an in vivo model by inducing cell apoptosis and inhibiting angiogenesis (Cui et al., 2010).