The use of Drosophila models of various neurodegenerative diseases already revealed valuable findings, such as essential insights into the pathology of Alzheimer’s disease (AD) (Williams et al., 2000; Wittmann et al., 2001; Shulman and Feany, 2003; Finelli et al., 2004) or the interaction of PINK1 and Parkin in PD (Clark et al., 2006; Park et al., 2006). Here, PRKN is linked to neurodegenerative disease.