In chronic PD mice produced by MPTP and probenecid, plumbagin decreased TLR2, and TLR4 protein expressions blocked the nuclear translocation of NF-κB p65 protein (Figures 2(f)–2(j)) and suppressed the production of TNF-α, IL-1β, and IL-6 mRNA (Figure 2(l)). This evidence concerns the gene IL1B and Parkinson disease.