IRS2 and obesity due to melanocortin 4 receptor deficiency: However, the genetic variant of IRS2 Gly1057Asp was significantly associated with risk of T2D only in female Bangladeshi population, not males, and the authors were unable to replicate the association of IRS2 Gly1057Asp with obesity [80], while no association with obesity has been found in obese Polish pregnant women [81], implying more appropriate controls for related confounding factors, and a larger sample size is required to confirm this finding.