In contrast the effects of Tau on ISP on 293 T cells, the non-neuronal cells, as described in the above results, WTau or PTau overexpressing in the human neuroblastoma cell line SH-SY5Y cells also showed deregulation of ISP, with a slight increasing tendency of p-IRS the upstream factor of ISP, but a significant increase in p-S6 (p < 0.05) in basal conditions (Figures 7A,B). The gene discussed is RPS6; the disease is neuroblastoma.