MAPT and Alzheimer disease: The maladjustment of this signaling by Tau overexpressing and its phosphorylated form may be important because this static hyper-ISP leads to or is accompanied by the impairment of physiological fluctuations in neuronal functions, which may directly contribute to AD pathogenesis (Caccamo et al., 2010; Tramutola et al., 2015; Mueed et al., 2018).