MAPT and Alzheimer disease: In addition to α-synuclein, there were also Alzheimer's disease (AD)-like pathological changes in the brains of patients with PD, including β amyloid (Aβ)1 − 42 and phosphorylated tau (P-tau) (Compta and Revesz, 2021), the main components of neuroinflammatory plaques and neurofibrillary tangles in the brains of patients with AD, respectively.