From a neuropathological perspective, AD is characterized by the accumulation of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles of phosphorylated tau protein (p-tau) in the brain, which initiates a neurotoxic cascade of progressive neuronal and synaptic loss in the hippocampus and surrounding medial temporal lobe (Bloom, 2014), and general brain atrophy (Pini et al., 2016). This evidence concerns the gene MAPT and Global brain atrophy.