SIRT1 and hypertensive disorder: Moreover, the development of hypertension and vascular damage in the thoracic aorta induced by HFD was prevented by activation of TRPV1 and this was accompanied by upregulation of PPAR-α, sirtuin-1 (central cellular metabolic sensor; SiRT-1), and PGC-1α (Schilling, et al., 2017).