Based on the association to top comorbidities and ACE2 and TMPRSS2 similarity scores, 17 drug target genes were identified, Marketed drugs for identified genes are indicated for the treatment of hypertension, heart failure, kidney failure, lung cancer, diabetes mellitus, emphysema, pulmonary obstruction, acute coronary syndrome, allergic rhinitis, inflammation, diabetic foot fever, diabetes mellitus, rheumatic disease and generalized lipodystrophy (Table 1). The gene discussed is TMPRSS2; the disease is rheumatic disorder.