Cigarette smoking causes dysregulation of TLRs and NF-κB (Yang et al., 2006; Semlali et al., 2012), which plays an important role in the pathogenesis of various diseases, including atherosclerosis (Hovland et al., 2015; Salvador et al., 2016), type 2 diabetes (Jialal et al., 2014; Aly et al., 2020), hypertension (Lazaridis et al., 2021), and others more. The gene discussed is NFKB1; the disease is type 2 diabetes mellitus.