Emerging evidence from human clinical trials and animal studies suggests that hyperinsulinemia and brain insulin resistance also are involved in the developmental process through multiple pathways, including a decreased clearance of amyloid-β-peptide and phosphorylation of τ protein, hallmarks of AD, and through effects on vasoreactivity, lipid metabolism, and inflammation (Fishel, et al., 2005; Verdile et al., 2015; Kellar and Craft, 2020). This evidence concerns the gene TBXT and Alzheimer disease.