A clinical study in type 2 diabetic patients with or without renal insufficiency showed that the expression of TLR2 and TLR4 was higher in patients with renal insufficiency than in patients without renal insufficiency or in normal subjects and correlated positively with the degree of insulin resistance and negatively with the degree of insulin sensitivity (Aly et al., 2020). The gene discussed is INS; the disease is Insulin resistance.