ACE and Hypertension: As an example, we considered approaches to the treatment of arterial hypertension using different pharmacological effects of medicines, including angiotensin II receptor blockade (losartan), calcium channel blockade (amlodipine), angiotensin-converting enzyme inhibition (enalapril), direct renin inhibition (aliskiren), the action of thiazide diuretics (hydrochlorothiazide), and β-blockade (bisoprolol).