In the PAH rat model, inhibition of mitochondrial fusion protein DRP1/NADPH oxidase (NOX) pathway and autophagy related protein (Atg) - 5/Atg-7/Declin-1/microtubule related protein light chain 3 (LC3) dependent autophagy pathway in PASMCs can reduce PASMCs proliferation (Wu et al., 2019). The gene discussed is DNM1L; the disease is pulmonary arterial hypertension.