From a clinical point of view, the optic neuropathies described by the authors were: retrobulbar (posterior) optic neuropathy in more cases [7,16,18], only one associated with MOG+ [7], anterior optic neuropathy (papillitis) [6,7], AION [2,13,14,18], from which one AAION [2] and the others NAION [13,14,18], one being related to pronation in an OTI patient with ARDS [14], neuroretinitis [18], suggested by the eye fundus with papillary edema with star-shaped associated with star-shaped macular exudates. This evidence concerns the gene MOG and optic nerve disorder.