IL1B and gout: The beneficial effects of anakinra have been demonstrated in the treatment of a wide range of disorders, including auto-inflammatory disorders (Cavalli and Dinarello, 2018; Kuemmerle-Deschner et al., 2020), seizure (Lai et al., 2020), pericarditis (Khayata et al., 2020), and gout (Janssen et al., 2019), wherein the pathogenesis is associated with an excessive IL-1β expression.