MKI67 and neoplasm: The cluster of differentiation CD68, overexpressed in TAMs, not only indicates the amoeboid, phagocytic phenotype of those cells (da Silva and Gordon, 1999) but it is also related to a higher-grade tumor, Ki67 positivity, and tumor aggressiveness (Sun et al., 2016; Zhu et al., 2016; Ni et al., 2019).