CCN4 and cancer: At the transcriptional level, we found significant differences in CCNs associated cancer transcription factors in LGG versus normal brain tissue, with most being decreased, but HOXB7, the promoter of CCN4, was significantly increased 4.4-fold more than normal brain tissue (Figure 7J, Supplementary Table S2), demonstrating that promoter changes were an important part involved in the dysregulation of CCN genes expression.