In addition, we explored the biological functions of CCNs in LGG, and we found that CCNs were also closely associated with gene mutations, high-inflammation, high-ECM, high-stemness, metabolic abnormalities and immune escape in LGG, in addition to malignant phenotypes such as tumor proliferation and invasion, and has important and specific research value in LGG. Here, CCNL2 is linked to neoplasm.