Therefore, we analyzed tumor mutational burden (TMB), single nucleotide variants (SNV) neoantigens, including insertional deletion mutations (indel), silent and non-silent mutations, major histocompatibility complex-related genes (MHC), MHC-binding SNV-derived peptides (pMHC) and immunogenic death including autophagy, necroptosis, ferroptosis and pyroptosis. This evidence concerns the gene HLA-C and neoplasm.